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Lymphogranuloma venereum (LGV) (also known as "Climatic bubo",〔 "Durand–Nicolas–Favre disease",〔 "Poradenitis inguinale",〔 and "Strumous bubo") is a sexually transmitted disease caused by the invasive serovars L1, L2, L2a or L3 of ''Chlamydia trachomatis''. LGV is primarily an infection of lymphatics and lymph nodes. ''Chlamydia trachomatis'' is the bacterium responsible for LGV. It gains entrance through breaks in the skin, or it can cross the epithelial cell layer of mucous membranes. The organism travels from the site of inoculation down the lymphatic channels to multiply within mononuclear phagocytes of the lymph nodes it passes. In developed nations, it was considered rare before 2003. However, a recent outbreak in the Netherlands among gay men has led to an increase of LGV in Europe and the United States.〔Thomas H. Maugh II. (Virulent Chlamydia Detected Largely Among Gay Men in U.S. ) Los Angeles Times: 11 May 2006〕〔Michael Brown. (LGV in the UK: almost 350 cases reported and still predominantly affecting HIV-positive gay men ) Aidsmap: 17 May 2006〕 A majority of these patients are HIV co-infected. LGV was first described by Wallace in 1833 and again by Durand, Nicolas, and Favre in 1913. Since the 2004 Dutch outbreak many additional cases have been reported, leading to greater surveillance. Soon after the initial Dutch report, national and international health authorities launched warning initiatives and multiple LGV cases were identified in several more European countries (Belgium, France, the UK, Germany, Sweden, Italy and Switzerland) and the US and Canada. All cases reported in Amsterdam and France and a considerable percentage of LGV infections in the UK and Germany were caused by a newly discovered Chlamydia variant, L2b, a.k.a. the Amsterdam variant. The L2b variant could be traced back and was isolated from anal swabs of men who have sex with men (MSM) who visited the STI city clinic of San Francisco in 1981. This finding suggests that the recent LGV outbreak among MSM in industrialised countries is a slowly evolving epidemic. The L2b serovar has also been identified in Australia. ==Signs and symptoms== The clinical manifestation of LGV depends on the site of entry of the infectious organism (the sex contact site) and the stage of disease progression. * Inoculation at the mucous lining of external sex organs (penis and vagina) can lead to the inguinal syndrome named after the formation of buboes or abscesses in the groin (inguinal) region where draining lymph nodes are located. These signs usually appear from 3 days to a month after exposure. * The rectal syndrome arises if the infection takes place via the rectal mucosa (through anal sex) and is mainly characterized by proctocolitis symptoms. * The pharyngeal syndrome is rare. It starts after infection of pharyngeal tissue, and buboes in the neck region can occur. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lymphogranuloma venereum」の詳細全文を読む スポンサード リンク
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